complement receptor การใช้

• Co-stimulation for B cells is provided alternatively by complement receptors.
• It functions as a complement receptor.
• In mice, CR1 is an alternatively spliced variant of the complement receptor 2 ( CR2 ) gene.
• Helmy et al . identified a receptor present in Kupffer cells, the complement receptor of the immunoglobulin family ( CRIg ).
• As well as endocytic PRRs, phagocytes also express opsonin receptors such as Fc receptor and complement receptor 1 ( CR1 ).
• In human mononuclear phagocytes, phagocytosis of " Mycobacterium tuberculosis " is mediated in part by human monocyte complement receptors including CR3.
• The mean number of complement receptor 1 ( CR1 ) molecules on erythrocytes in normal individuals lies within the range of 100-1000 molecules per cell.
• As well as endocytic PRRs, phagocytes also express opsonin receptors Fc receptor and complement receptor 1 ( CR1 ), which bind to antibodies and C3b, respectively.
• Conversely, complement receptor-mediated pathogen ingestion occurs without observable membrane extensions ( particles just sink into the cell ) and does not generally results in an inflammatory mediator response.
• The canonical Cr2 / CD21 gene of subprimate mammals produces two types of complement receptor ( CR1, ca . 200 kDa; CR2, ca . 145 kDa ) via alternative mRNA splicing.
• Because primate erythrocytes express complement receptor 1 ( CR1 ) on their surface and having binding specificity to C4b, C3b, or iC3b, erythrocytes accumulate on the microbe via CR1-complement binding.
• Dr . Lambris'laboratory was among the first to study the critical sites of complement component C3 responsible for its diverse functions and also to define its complex binding dynamics to various C3 natural ligands, viral proteins, complement receptors, and regulators.
• Complement receptor type 1 ( C3b / C4b receptor ) ( Antigen CD35 ) belongs to the Knops blood group system and is associated with Kn ( a / b ), McC ( a ), Sl ( a ) and Yk ( a ) antigens.
• After C3b is degraded into a fragment iC3b ( inactive derivative of C3b ), then cleaved to C3dg, and finally to C3d, which continue to bind to microbal surface, B cells express complement receptor CR2 ( CD21 ) to bind to iC3b, C3dg, or C3d.
• The CR2 gene of primates produces only the smaller isoform, CR2; primate complement receptor 1, which recapitulates many of the structural domains and presumed functions of Cr2-derived CR1 in subprimates, is encoded by a distinct CR1 gene ( apparently derived from the gene Crry of subprimates ).
• The complement receptor 2 ( CR2 ) gene of primates produces only the smaller isoform, CR2; primate CR1, which recapitulates many of the structural domains and presumed functions of Cr2-derived CR1 in subprimates, is encoded by a distinct CR1 gene ( apparently derived from the gene Crry of subprimates ).